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呼吸链的类型

  1. NADH氧化呼吸链: 主要的呼吸链

  2. 琥珀酸氧化呼吸链(FADH2氧化呼吸链)

四种具有传递电子功能的酶复合体

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泛醌 (辅酶Q)和 Cyt c 均不包含在上述四种复合体中;是递氢体,也是递电子体;能在线粒体内膜中迅速扩散

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Q循环

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确定呼吸链各组分的排列顺序

  1. 根据各组分的标准氧化还原电位E0’(由低到高的顺序排列——— 高-易得电子-电子流向)
  2. 根据在有氧环境下,氧化反应达到平衡时各电子传递体的还原程度
  3. 使用特异性呼吸链抑制剂和人工电子受体

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Q——交汇点

复合体Ⅰ:NADH-Q还原酶

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每传递2个电子可将4个H+从内膜基质侧泵到胞浆侧,复合体Ⅰ有质子泵功能。

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NAD+(NADP+)和NADH(NADPH)相互转变

氧化还原反应时变化发生在五价氮和三价氮之间。

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FMN结构中含核黄素,发挥功能的部位是异咯嗪环,氧化还原反应时不稳定中间产物是FMNH•

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铁硫蛋白中辅基铁硫簇(Fe-S)含有等量铁原子和硫原子,其中铁原子可进行Fe2+ ←→Fe3++e 反应传递电子

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辅酶QCoQ, Q,泛醌)由多个异戊二烯连接形成较长的疏水侧链(人CoQ10),脂溶性辅酶————递氢,递电子

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复合体Ⅱ: 琥珀酸-Q还原酶

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复合体Ⅱ没有H+泵的功能

复合体Ⅲ: 辅酶Q-细胞色素c还原酶

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复合体Ⅲ每传递2个电子向内膜胞浆侧释放4个H+,复合体Ⅲ也有质子泵作用

细胞色素(cytochrome, Cyt)

细胞色素是一类以铁卟啉为辅基的催化电子传递的酶类,根据它们吸收光谱不同而分类

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复合体Ⅳ: 细胞色素c氧化酶

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每2个电子传递过程使2个H+跨内膜向胞浆侧转移,复合体Ⅳ也有质子泵作用。