Noncoding translation mitigation

Non-coding transcript variants of protein-coding genes – what are they good for?

DNA - HGP-noncoding RNA

<aside> ⭕ Non-coding RNA (ncRNA)

a RNA molecule that functions without being translated into a protein.

Tip: some long non-coding RNAs have been re-defined as micropeptide or microprotein encoding transcripts, and in turn some protein-coding RNAs are bifunctional and display also non-coding functions.

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非编码RNA功能的发现

• The first discovered miRNA lin-4 in 1993

  Breakthrough with BlastN of the second miRNA (stRNA) let-7

  MicroRNAs: 22-25 nt Noncoding RNAs

• Discovery of siRNA in 1998

  • siRNA-Mediated Gene Silencing
  • siRNA ，miRNA
  • RNA-Mediated Gene Silencing

• A myriad of RNAs and functional diversity

  • mRNA, tRNA, rRNA: protein biosynthesis
  • 长链非编码RNA（lncRNA）
  • Telomerase RNA: DNA replication and life
  • gRNA: mRNA editing
  • snRNA: mRNA processing (splicing and maturation)
  • snoRNA: rRNA processing( cleavage and modification)
  • RNA P: tRNA processing
  • SRP-RNA: transport
  • miRNA: regulation of gene expression in transcription and post-transcription levels
  • siRNA: gene silence
  • Xist and Tsix: X chromosome inactivation

非编码RNA 与 肺癌

• [ ] 肺癌：常见的肺原发性恶性肿瘤- - - 多起源与支气管粘膜上皮

  小细胞肺癌（SCLC）、非小细胞肺癌（NSCLC）【80%】

• 与肺癌相关的miRNA

• 诊断和治疗

• 主要的研究任务

• EML4-ALK 肺癌的驱动基因

• [ ] 精准医学 Precision Medicine

  

• 免疫治疗的新进展：PD-1