Vaculation of the cytoplasm
Breakdown of the plasma membrane
Induction of inflammation around the dying cell attributable to the release of cellular contents and proinflammatory molecules.
Nuclear morphology change without the organized chromatin condensation and fragmentation of DNA into 200 bp fragments that is characteristic for apoptosis cell death
琼脂糖凝胶电泳时呈现弥散性分布,俗称“拖尾”现象。
The end result of a bioenergetic catastrophe resulting from ATP depletion to a level incompatible with cell survival and was thought to be initiated mainly by cellular “accidents” such as toxic insults or physical damage.
A passive form of cell death with more similarities to a train wreck than a suicide.
Caspase-independent cell death is observed in many systems indicating that cells still die even if the executioner is absent.
Caspase-independent necrotic cell death can be forestalled by treatment with antioxidants or by eliminating the activity of the protein linase RIP. These results led to the idea that the necrosis could be “programmed”.
[ ] Necrosis may be a physiologically relevant process
Many viruses carry genes that inhibit apoptosis thereby prolonging the life of their host cell and foiling the cell’s attempt to limit its use as a virus-producing factory by initiating apoptosis. Recent study indicates that viruses also carry genes to suppress programmed necrosis, the back-up mechanism that infected cells use for suicide. These observations establish a physiological role for programmed necrosis in mammalian cells.