Chapter 3 cytokine

Overview

Interferon(干扰素）：a2b

Therapy：

infection : Hepatitis Virus B（乙型肝炎）, C

Cancers (+ chemotherapy /radiation ) : hematological malignancy(恶性血液肿瘤）， melanomas leukemia（黑色素瘤白血病） and lymphomas.

• Cytokines : low MV proteins(低分子量蛋白）secreted（分泌）that regulate intercellular action during immune response.
• Previously classification

Monokines-mononuclear-Macrophage

Lymphokines-activated T cell, especially T H

Interleukins（白介素）-Leukocytes etc.

• Cytokine nomenclature（术语）

Interleukin白介素

Properties and function of Cytokines

• Properties
• Biological Function

Typical cytokines and their functions

• The major cytokines mediate innate immunity
• Major cytokine evolved in adaptive immunity