Bcl-2家族参与调控胞内信号激活线粒体介导的细胞凋亡途径。

Bcl 2 proteins: the key regulator of the intrinsic pathway

The role of BH123 (mainly by Bax and Bak ) in the release of mitochondrial intermembrane proteins in the intrinsic pathway of apoptosis.

How pro-apoptotic BH3-only and anti-apoptotic Bcl2 proteins regulate the intrinsic pathway of apoptosis.

胞内信号激活线粒体介导的细胞凋亡途径

细胞内损伤（DNA损伤、氧化应激等）→激活Bcl-2家族成员（Bad、Bax）→Bax插入线粒体外膜→细胞色素C释放→细胞色素C结合Apaf-1和Procaspase-9→激活Caspase-9→激活下游级联反应→细胞凋亡。

Bcl 2 proteins: the key regulator of the intrinsic pathway

The intrinsic pathway of apoptosis is tightly controlled

The extrinsic pathway also recruit the intrinsic pathway to amplify the apoptotic signal to kill the cell