Ag presentation cells ( APC)：Mφ巨噬细胞，DC，B

Antigen presentation by Macrophage

Antigen capture

– Endocytosis胞吞 big granular Ag – pinocytosis胞饮 resolve Ag – receptor-mediated endosytosis （granular or resolve Ag）

<aside> ⚙ Ag——>vesicles——>lysosome——>degraded

———>Rejected(most)

———>residues

———>Ag presentation

</aside>

Ag presentation by DC

• Methods of Ag capture

– pinocytosis （strong） – receptor-mediated endosytosis

• receptor：FcyR II, mannose receptor

• Ag presentation

Ag presentation by B cell

Method of Ag capture

—inocytosis （strong） —receptor-mediated endosytosis

Ag presentation

Antigen process

Ag-MHC I complex assembly and transport ---——- cytosolic 细胞溶质的 pathway

• MHC 1 pathway(cytosolic pathway)
• Endocytic pathway
• CD1 pathway